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Mutation of Tyr245 or Tyr305 in SET7/9 (Determine 4b ) alters its [specificity](http://ukunis.uk/agent/haimatthes1898/) from an H3 K4 mono-methylase to a tri- and di-methylase, respectively 16 , 21 , whereas an Phe281Tyr mutation in the lysine-binding pocket of DIM-5 (Determine 4c ) converts this protein to an H3 K9 mono- or di-methylase sixteen These mutations exemplify the F/Y switch (Determine 1 ) that establishes SET-area product specificities.
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It has been shown that with an advancing age, muscle protein synthesis (MPS) response to a smaller ingestion of EAAs (7 g) was reduced in older people as compared to young people 25 , which was overcome by a bigger ingestion of EAAs (15 g) 26 Due to this fact, it's worth investigating whether ingestion of lower doses of lysine as in the case of the present examine might enhance glucose metabolism in healthy young adults.
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